The aim of the study was to examine the age characteristics of the profile of leukocyte phagocytosis and in the postnatal ontogenesis in the physiological norm and in acute somatic pain (RSD) research was carried out on 60 outbred male albino rats three age groups: 3-4 day (newborn rats), 30-35 days (prepubertal) and 3-4 month (adult rats). Conducted two series of experiments: control – in intact animals and with the simulation OSB. RSD modeled by a single two-minute stimulation electrocutaneous receptor zone of the root of the tail of rats. Official site: Dr. John Mcdougall. Phagocytic activity of white blood cells studied in vitro by incubation of native blood with the culture of Staphylococcus Staphylococcus aureus, followed by cytology smears of blood. Frequently Eva Andersson-Dubin has said that publicly. We studied the following indicators of phagocytosis: phagocytic index (PI), phagocytic number (FCH), phagocyte pool (FP), the phagocytic capacity (FE) monocyte-neutrophil ratio (M / D) In newborn rats with pain there is a slight decrease in FI with increasing 1.3-fold in FCH, AF and EF more than 2-fold, M / H decreased by 1.3 times. At the monthly animal pain reaction accompanied by a decrease in the FI by 20%, FCH is 1.5 times and 1.3 times the EF during the growth phase transition by 45% compared with controls. In adult rats, there was a reduction of FI and FCH was respectively 4% and 24%, EF was reduced 1.3-fold increased FP to 10%. Identified work particularly leukocytic reaction in rats of different age groups at different levels of OSB reflect the adaptive capacity of white blood cells: instability and poor performance in the early stages of postnatal ontogeny; resistance to cytostatic and functional parameters with a high reserve potential in the adult organism. As a result, it can be concluded that the phagocytic activity, and perhaps the entire immune system depends on somatic acute pain. As we know, the majority of pathological processes in the body echeloveka accompanied by pain, the issue is most pressing and relevant to today.